Overexpression of Platelet-Derived Growth Factor Receptor Α D842V Mutants Prevents Liver Regeneration and Chemically Induced Hepatocarcinogenesis via Inhibition of MET and EGFR

In conclusion, continuous activation of PDGFRα signaling by expression of PDGFRαD842V does not promote, but inhibit hepatic regeneration and hepatocarcinogenesis, possibly through compensatory downregulation of MET and EGFR.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhao-Qing Du, Jian Dong, Mu-Xing Li, Jian-Fei Zhang, Jian-Bin Bi, Yi-Fan Ren, Li-Na Zhang, Rong-Qian Wu, Satdarshan P.S. Monga, Yi Lv, Xu-Feng Zhang, Hai-Chen Wang Tags: Research Paper Source Type: research