LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway

Conclusions: The H19/miR-675-3p signaling axis plays a critical role in maintaining the EMT process and stemness of PC cells by directly targeting SOCS5 to activate the STAT3 pathway. These data provide new insights into the oncogenic function of H19 in human PC and reveal potential targets for the development of optimal treatment approaches for this disease.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Feng Wang, Long Rong, Zhengkui Zhang, Mingzhe Li, Ling Ma, Yongsu Ma, Xuehai Xie, Xiaodong Tian, Yinmo Yang Tags: Research Paper Source Type: research