Polyprenylated Acylphloroglucinols as Deubiquitinating protease USP7 inhibitors from Hypericum hookerianum.

Polyprenylated Acylphloroglucinols as Deubiquitinating protease USP7 inhibitors from Hypericum hookerianum.
Fitoterapia. 2020 Jun 25;:104678
Authors: Wang QQ, Wang XD, Wu LZ, Fang QQ, Liu YN, Jiang K, Qu SJ, Tan CH
Abstract
Hookerianones A - E (1-5), five new polyprenylated acylphloroglucinols (PPAPs), along with six known ones, were isolated from the aerial parts of Hypericum hookerianum. Their structures were elucidated by analyses of MS, NMR, chiroptical properties, biogenetic pathway, and/or single crystal X-ray diffraction. A ubiquitin-rhodamine 110 assay showed that furohyperforin and hypercalin C, two representative PPAPs in this plant, inhibited more than 90% USP7 at the concentration of 10 μM.
PMID: 32593692 [PubMed - as supplied by publisher]

Source: Fitoterapia - June 24, 2020 Category: Biochemistry Authors: Wang QQ, Wang XD, Wu LZ, Fang QQ, Liu YN, Jiang K, Qu SJ, Tan CH Tags: Fitoterapia Source Type: research