Linking genotype, cell behavior, and phenotype: multidisciplinary perspectives with a basis in zebrafish patterns.

Linking genotype, cell behavior, and phenotype: multidisciplinary perspectives with a basis in zebrafish patterns.
Curr Opin Genet Dev. 2020 Jun 27;63:78-85
Authors: Volkening A
Abstract
Zebrafish are characterized by dark and light stripes, but mutants display a rich variety of altered patterns. These patterns arise from the interactions of brightly colored pigment cells, making zebrafish a self-organization problem. The diversity of patterns present in zebrafish and other emerging fish models provides an excellent system for elucidating how genes, cell behavior, and visible animal characteristics are related. With the goal of highlighting how experimental and mathematical approaches can be used to link these scales, I overview current descriptions of zebrafish patterning, describe advances in the understanding of the mechanisms underlying cell communication, and discuss new work that moves beyond zebrafish to explore patterning in evolutionary relatives.
PMID: 32604031 [PubMed - as supplied by publisher]

Source: Current Opinion in Genetics and Development - June 26, 2020 Category: Genetics & Stem Cells Authors: Volkening A Tags: Curr Opin Genet Dev Source Type: research