Lung Ultrasound and Clinical Progression of Acute Bronchiolitis: A Prospective Observational Single-Center Study.

Lung Ultrasound and Clinical Progression of Acute Bronchiolitis: A Prospective Observational Single-Center Study. Medicina (Kaunas). 2020 Jun 26;56(6): Authors: Di Mauro A, Cappiello AR, Ammirabile A, Abbondanza N, Bianchi FP, Tafuri S, Manzionna MM Abstract Background and Objectives: Recent literature suggests that lung ultrasound might have a role in the diagnosis and management of bronchiolitis. The aim of the study is to evaluate the relationship between an ultrasound score and the clinical progression of bronchiolitis: need for supplemental oxygen, duration of oxygen therapy and hospital stay. Materials and Methods: This was a prospective observational single-center study, conducted in a pediatric unit during the 2017-2018 epidemic periods. All consecutive patients admitted with clinical signs of acute bronchiolitis, but without the need for supplemental oxygen, underwent a lung ultrasound in the first 24 h of hospital care. The lung involvement was graded based on the ultrasound score. During clinical progression, need for supplemental oxygen, duration of oxygen therapy and duration of hospital stay were recorded. Results: The final analysis included 83 patients, with a mean age of 4.5 ± 4.1 months. The lung ultrasound score in patients that required supplemental oxygen during hospitalization was 4.5 ± 1.7 (range: 2.0-8.0), different from the one of the not supplemented infants (2.5 ± 1.8; range: 0.0-6.0; p
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research

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ConclusionsThe study identified distinct clinical profiles of bronchiolitis by a clustering approach in a single-centre study of children hospitalised for bronchiolitis in Italy. The three bronchiolitis profiles share some similarities with those identified in international studies using the same statistical approach. These findings may help to increase the understanding of the phenotypic variability that typically characterizes bronchiolitis, with relevant implications for future research.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
The objectives of this article are: a) to evaluate the influence of climatic conditions on hospital admissions for asthma and lower respiratory tract infections (LRTIs) among children and adolescents living in Belo Horizonte during the period 2002 to 2012 and identify epidemic peaks of admissions for asthma; b) to compare local seasonal patterns of admissions for asthma and LRTIs. Using hospital admission data stratified by aged group, regression analysis was performed to determine the relationship between the variables. Epidemic peaks were identified using an ARIMA model. There was an increase in admissions for asthma wit...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
The objectives of this article are: a) to evaluate the influence of climatic conditions on hospital admissions for asthma and lower respiratory tract infections (LRTIs) among children and adolescents living in Belo Horizonte during the period 2002 to 2012 and identify epidemic peaks of admissions for asthma; b) to compare local seasonal patterns of admissions for asthma and LRTIs. Using hospital admission data stratified by aged group, regression analysis was performed to determine the relationship between the variables. Epidemic peaks were identified using an ARIMA model. There was an increase in admissions for asthma wit...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
Conclusions: We elucidated the presence of different endotypes in infants with RSV sole bronchiolitis. Previously healthy full-term infants hospitalized during the nonpeak months seem to be more likely those with a possible predisposition to atopy.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Immunology and Host Response Source Type: research
Conclusions: The aminoacid changes detected in the hypervariable part of the G protein may have altered functions and/or changed its immunogenicity determining an impact on disease severity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
Rationale: We aimed to study wheezing recurrence after bronchiolitis from different RSV genotypes: RSVA NA1 and ON1, and RSVB BA.Methods: We prospectively enrolled term infants
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
Introduction: Respiratory syncytial virus (RSV) A ON1, firstly detected in 2010, has progressively replaced the previous circulating subtype RSV A NA1.Aims and Objectives: The aim of our study was to compare the clinical severity of RSV A ON1 bronchiolitis in hospitalised children over six epidemic seasons.Methods: We enrolled 497 patients younger than 12 months, hospitalised for RSV bronchiolitis, through the epidemic seasons 2005/2006-2017/2018. We analyzed the genotype in 391 samples and selected the RSV A ON1 positive patients. For each patient, demographic and clinical data were collected from clinical records. A seve...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
Introduction: Bronchiolitis is the most common cause of hospitalization in infants and recent evidences in literature suggest its heterogeneity.Aims and Objectives: Our aim was to investigate whether different clinical profiles exist among infants hospitalised with bronchiolitis.Methods: we consecutively enrolled children
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
Background: Recent literature suggests that lung ultrasound might have a role in diagnosis and management of bronchiolitisAim: Aim of the study is to evaluate the relationship between a previous published ultrasound score (1) in the first 24 hours of hospital care and the clinical progression of bronchiolitis: need for supplemental oxygen, duration of oxygen therapy and hospital stayMethods: This was a prospective observational single-center study, conducted in a Paediatric Unit during the 2017-2018 epidemic periodsAll consecutive patients admitted with clinical signs of acute bronchiolitis underwent a lung ultrasound in t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Neonatology and paediatric intensive care Source Type: research
AbstractBackgroundThe only pharmacologic prophylaxis against respiratory syncytial virus (RSV) infection in preterm infants is the humanized monoclonal antibody palivizumab. After the 2014 modification of the American Academy of Pediatrics (AAP) recommendations, the Italian Medicines Agency (AIFA) limited the financial coverage for palivizumab prescriptions to otherwise healthy preterm infants with
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
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