Optimal Oxygen Targets in Term Lambs with Meconium Aspiration Syndrome and Pulmonary Hypertension.

CONCLUSIONS: In term lambs with MAS and PPHN, Qp and bDO2 over the first 6h are higher by targeting SpO2 in the 95-99% range. However, 90-94% target range is associated with significantly lower FiO2 and lung oxidative stress. Clinical trials comparing 90-94% vs. 95-99% SpO2 target range in term infants with PPHN are warranted.
PMID: 32609558 [PubMed - as supplied by publisher]

Source: Am J Respir Cell Mol... - June 30, 2020 Category: Respiratory Medicine Authors: Rawat M, Chandrasekharan P, Gugino SF, Koenigsknecht C, Nielsen L, Wedgwood S, Mathew B, Nair J, Steinhorn R, Lakshminrusimha S Tags: Am J Respir Cell Mol Biol Source Type: research