A case of autoimmune polyendocrine syndrome type 3 (APS ‐3) complicated with anti‐N‐methyl‐D‐aspartic acid‐receptor (NMDA‐R) encephalitis

We report a rare case of autoimmune polyendocrine syndrome type 3 (APS‐3) complicated by anti‐NMDA‐R encephali tis. After hospitalization for type 1 diabetes the 39‐year‐old patient developed various schizophreniform symptoms and seizures following cold‐like symptoms. These findings are consistent with the diagnosis of anti‐NMDA‐R encephalitis. Immune‐related encephalitis was suspected at the ear ly phase of the disease and cerebrospinal fluid was positive for anti‐NMDA‐R antibody. Early steroid pulse therapy was initiated during the disease course. The condition improved gradually to full recovery. Early detection and treatment of anti‐NMDA‐R encephalitis should enhance positive out come, considering that besides thyroid diseases and type 1 diabetes, various autoimmune diseases are associated with APS‐3.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: CASE REPORT Source Type: research