Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a {beta}-Amyloidosis Mouse Model with 11C-Metoclopramide PET

Conclusion: 11C-metoclopramide can measure ABCB1 induction in the mouse brain without the need to consider an arterial input function and may find potential application in Alzheimer disease patients to noninvasively evaluate strategies to enhance the clearance properties of the BBB.

Source: Journal of Nuclear Medicine - June 30, 2020 Category: Nuclear Medicine Authors: Zoufal, V., Mairinger, S., Brackhan, M., Krohn, M., Filip, T., Sauberer, M., Stanek, J., Wanek, T., Tournier, N., Bauer, M., Pahnke, J., Langer, O. Tags: Basic Source Type: research