Facts and hopes in immunotherapy of soft tissue sarcomas.

Facts and hopes in immunotherapy of soft tissue sarcomas. Clin Cancer Res. 2020 Jun 29;: Authors: Martín-Broto J, Moura DS, Van Tine BA Abstract Sarcomas are mesenchymal tumors, encompassing more than 175 subtypes, each one with their own genetic complexities. As a result, immunotherapy approaches have not been universally successful across the wide rage of diverse subtypes. The actual state of science and the current clinical data utilizing immunotherapy within the soft tissue sarcomas (STS) will be detailed in this review. More precisely, the review will focus on: a) the role of the immune microenvironment in the development and activity of new therapeutic approaches; b) the recent identification of the sarcoma immune class (SIC) groups, especially group SIC E with its B cell signature that predicts immunotherapy response; c) the clinical trials using PD-1 and/ or CTLA-4 inhibitors, which serves as reference for response data, d) the promising clinical activity from the combination of anti-angiogenics agents with PD-1 inhibitors E) the adapted T-cell therapies for synovial sarcoma that target either NY-ESO or MAGEA4; and F) the role for localized therapy using the virotherapy T-VEC with PD-1 inhibitors. Herein we present the facts and the hopes for the sarcoma patients, as the field is rapidly advancing its understanding of what and where to use the various types of immunotherapies. PMID: 32601077 [PubMed - as supplied by ...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research