Response to letter to the editor- J Hennessey re clinical parameters and thyroid hormone levels.

Response to letter to the editor- J Hennessey re clinical parameters and thyroid hormone levels. Thyroid. 2020 Jun 29;: Authors: Fitzgerald SP, Bean NG, Falhammar H Abstract We are grateful to Hennessey (1) for providing the opportunity to further clarify the conclusions and implications of our work (2). These are more radical than Hennessey has indicated. We believe the accumulated theoretical and empiric evidence indicates we should be discussing(a) abandoning the term 'subclinical thyroid dysfunction' and replacing it with 'compensated euthyroidism', (b)the adoption of FT4 levels in place of TSH levels as the first step/screening test for clinical assessment of thyroid function, (c) placing greater importance on the presence of abnormal thyroid hormone levels in the presence of normal TSH levels (isolated hypo/hyperthyroxinemia), and (d) in the research setting, replacing the study of 'subclinical thyroid dysfunction' (the study of isolated TSH abnormalities)with the study of cohorts of individuals with borderline thyroid hormone levels. PMID: 32600115 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research