An overview of the human brain myelin proteome and differences associated with schizophrenia.

CONCLUSIONS: Together these findings suggest disruptive effects on synaptic activity and therefore neural transmission and connectivity, consistent with the dysconnectivity hypothesis of schizophrenia. Further studies on these proteins may lead to the identification of potential drug targets related to the synaptic dysconnectivity in schizophrenia and other psychiatric and neurodegenerative disorders. Main PointsWe have carried out the characterization of the human brain myelinome.Many of the proteins were altered in schizophrenia, with synaptic and energy metabolism roles.These proteins might represent potential drug targets for schizophrenia. PMID: 32602824 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research