Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain

Conditions:   Pulsed Radiofrequency;   Osteoarthritis, Knee;   Knee Pain Chronic;   Knee Arthritis Intervention:   Device: Pulsed Radiofrequency Sponsor:   University of Rome Tor Vergata Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractMetalloproteinases were first identified as collagen cleaving enzymes and are now appreciated to play important roles in a wide variety of biological processes. The aberrant activity and dysregulation of the metalloproteinase family are linked to numerous diseases including cardiovascular and pulmonary diseases, chronic wounds, cancer, fibrosis and arthritis. Osteoarthritis (OA) is the most prevalent age-related joint disorder that causes pain and disability, but there are no disease-modifying drugs available. The hallmark of OA is loss of articular cartilage and elevated activities of matrix-degrading metalloprote...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
AbstractBackground Arthritis is a common chronic joint disease. It progressively causes joint pain, stiffness, and disability. Glucosamine sulfate has been shown to be an effective symptom-relieving biological agent. Pharmaceutical care, including patient counseling, is very important to overcome inconsistencies in compliance and adherence.Objective The aim of this study is to evaluate the impact of pharmaceutical care on the efficacy and safety of transdermal glucosamine sulfate and capsaicin (TGC-Plus cream) in the management of chronic joint pain.Settings A rheumatology outpatient clinic, Jordan University Hospital, Amm...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Conditions:   Knee Osteoarthritis;   Knee Arthritis;   Knee Pain Chronic;   Knee Disease;   Joint Pain;   Osteo Arthritis Knee;   Osteoarthritis, Knee Interventions:   Device: ROMTech PortableConnect;   Device: Traditional Rehabilitation and CPM Device Sponsor:   ROM Technologies, INC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Alahdal M, Duan L, Ouyang H, Wang D Abstract Osteoarthritis (OA) is a chronic degenerative joint disease and a leading cause of disability. It involves articular cartilage destruction and a whole joint inflammation. In spite of OA pathogenesis is still unclear, new studies on the OA pathophysiological aetiology and immunomodulation therapy continuously achieve significant advances with new concepts. Here, we focus on the indoleamine-2,3-dioxygenase1 (IDO1) activity in the osteoarthritis (OA), which is one of the noticeable enzymes in the synovial fluid of arthritis patients. It was recognized as an essenti...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Conditions:   Knee Osteoarthritis;   Knee Pain Chronic;   Knee Pain Swelling;   Knee Arthritis;   Arterial Occlusion Intervention:   Device: Genicular artery embolization (GAE) Sponsor:   Andrew Picel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractOsteoarthritis (OA) is a chronic degenerative joint disease, characterized by destruction of articular cartilage. This disease can markedly reduce quality of life of OA patients, leading to increased physical and psychological damage, for instance, pain and disability, and causing a serious impact on social economy.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
Abstract This systematic review assesses the literature regarding beneficial and potential detrimental effects of bioactive peptides (BPs), focusing on evidence of regulatory T cells (T-regs) mediated oral tolerance (OT), collagen hydrolysate (CH) supplementation in osteoarthritis (OA) and the association of T-regs with chronic disease. The systematic search was done for articles published from inception to April 2019 using the PubMed and Scopus databases. About 3081 papers were identified by three different search strategies and screened against inclusion criteria which resulted in the inclusion of 22 articles. F...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
Conditions:   Pulsed Radiofrequency;   Osteoarthritis, Knee;   Knee Pain Chronic;   Knee Arthritis Intervention:   Device: Pulsed Radiofrequency Sponsor:   University of Rome Tor Vergata Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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