USP7 manipulation by viral proteins.

USP7 manipulation by viral proteins.
Virus Res. 2020 Jun 27;:198076
Authors: Bojagora A, Saridakis V
Abstract
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then other DUB:viral protein interactions have been discovered, however, USP7 continues to be the most targeted DUB interacting with many proteins from various viruses. The selective pressures of evolution have allowed viruses to develop mechanisms that subvert host cellular machinery, promoting survival of the viral niche. Numerous viral proteins have been identified to target and usurp the function of USP7 to their advantage. This review explores novel developments in research focusing on the mechanisms underlying the manipulation of USP7 by viruses.
PMID: 32603670 [PubMed - as supplied by publisher]

Source: Virus Research - June 26, 2020 Category: Virology Authors: Bojagora A, Saridakis V Tags: Virus Res Source Type: research