The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice [Research Articles]

In conclusion, we have identified an lncRNA Gm15622/miR-742-3p/SREBP-1c regulatory circuit associated with NAFLD in mice, a finding that significantly advances our insight into how lipid metabolism and accumulation are altered in this metabolic disorder. Our results also suggest that Gm15622 may be a potential therapeutic target for managing NAFLD.

Source: The Journal of Lipid Research - June 30, 2020 Category: Lipidology Authors: Ma, M., Duan, R., Shen, L., Liu, M., Ji, Y., Zhou, H., Li, C., Liang, T., Li, X., Guo, L. Tags: Research Articles Source Type: research