EU reopening its borders, but not to Americans

The European Union will reopen its border to visitors from 15 countries but is barring any visitors from the United States. Holly Williams reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
The separation of the brain from blood by the blood-brain barrier and the bloodcerebrospinal fluid (CSF) barrier poses unique challenges for the discovery and development of drugs targeting the central nervous system (CNS). This review will describe the role of transporters in CNS penetration and examine the relationship between unbound brain (Cu-brain) and unbound plasma (Cu-plasma) or CSF (CCSF) concentration. Published data demonstrate that the relationship between Cu-brain and Cu-plasma or CCSF can be affected by transporter status and passive permeability of a drug and CCSF may not be a reliable surrogate for CNS pene...
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Advanced medical services and treatments are available for treating Tuberculosis. Related prevalence has increased in recent times. Unfortunately, the continuous consumption of related drugs is also known for inducing hepatotoxicity which is a critical condition and cannot be overlooked. The present review article has focused on the pathways causing these toxicities and also the role of enzyme CYP2E1, hepatic glutathione, Nrf2-ARE signaling pathway, and Membrane Permeability Transition as possible targets which may help in preventing the hepatotoxicity induced by the drugs used in the treatment of tuberculosis.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Conclusion: Imatinib is not a substrate of OCTs 1-3 while the environmental pH modulates cellular disposition of imatinib. The observation that a slightly acidic extracellular pH influences imatinib cellular accumulation is important, considering the low extracellular pH reported in the hematopoietic leukemia/ cancer cell microenvironment.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Conclusion: Special population plasma did not affect quantitation of drugs with a wide range of plasma protein binding levels in human plasma. With the confirmation that there is no impact on quantification from the matrix, the bioanalytical method can be used to support the pharmacokinetic evaluations for clinical studies in special populations.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Conclusion: This combination of in vitro assay and in vivo Cmax data provides a good approach to assess the inhibition of bovine medicines on bovine hepatic CYP450.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Conclusion: Pharmacodynamic studies in mice showed improved effectiveness of drug compared to pure drug. The oral bioavailability of AMS was improved from 48% to 78%.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Steroids, Volume 160Author(s):
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 30 June 2020Source: Pharmacology &TherapeuticsAuthor(s): Daniela Amaral Silva, David W. Pate, Robert D. Clark, Neal M. Davies, Ayman El-Kadi, Raimar Löbenberg
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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