Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease

ConclusionPNPLA3 genotype CG/GG and elevated BMI are the major predictors of significant fibrosis in prediabetic patients prior to intervention in this study. Mediterranean diet either alone or with silymarin treatment for 6  months leads to significant regression of liver damage and improvement of the glycemic profile in prediabetic patients. Yet, as combination treatment of silymarin with Mediterranean diet shows significant reduction of HbA1c when compared to diet alone, this suggests that silymarin may exert an ind ependent anti-glycemic action.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research