Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

Conclusion: Imatinib is not a substrate of OCTs 1-3 while the environmental pH modulates cellular disposition of imatinib. The observation that a slightly acidic extracellular pH influences imatinib cellular accumulation is important, considering the low extracellular pH reported in the hematopoietic leukemia/ cancer cell microenvironment.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research

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Conditions:   Hematologic Malignancy;   Leukemia;   Minimal Residual Disease;   Lymphoma;   Blood Cancer Intervention:   Diagnostic Test: Automated AI-Guided Diagnosis of Hematological Malignancies Sponsor:   Munich Leukemia Laboratory Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Chae HD, Dutta R, Tiu B, Hoff FW, Accordi B, Serafin V, Youn M, Huang M, Sumarsono N, Davis KL, Lacayo NJ, Pigazzi M, Horton TM, Kornblau SM, Sakamoto KM Abstract The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic mechanism has not been well characterized. Phosphorylated level of RSK (T573) was increased in acute myeloid leukemia (AML) patients and associated with poor survival. To examine the role of RSK in AML, we analyzed apoptosis and the cell cycle profile following treatment with BI-D1870, a potent inhibitor of RSK. BI-D1870 treatment increa...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
atsunskyi The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein ant...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Cancer patients are a population at high risk of contracting COVID-19 and, also of developing severe complications due to the infection, which is especially true when they are undergoing immunosuppressive treatment. Despite this, they had still to go to hospital to receive chemotherapy during lockdown. In this context, we have evaluated the psychological status of onco-hematological outpatients receiving infusion and not deferrable anti-neoplastic treatment for lymphoproliferative neoplasms, with the aim of both measuring the levels of post-traumatic symptoms, depression, and anxiety during the pandemic and also of investi...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Diffuse Large B Cell Lymphoma;   Primary Mediastinal Large B Cell Lymphoma;   Transformed Follicular Lymphoma to Diffuse Large B Cell Lymphoma;   Chronic Lymphocytic Leukemia;   Indolent Non-Hodgkin Lymphoma;   Marginal Zone Lymphoma;   Waldenstrom Macroglobulinemia;   Bur kitt's Lymphoma;   Primary CNS Lymphoma Intervention:   Drug: 19(T2)28z1xx CAR T cells Sponsors:   Memorial Sloan Kettering Cancer Center;   Takeda Recruiting
Source: - Category: Research Source Type: clinical trials
(Universitat Autonoma de Barcelona) The nanoparticle targets only leukemic cells and therefore would reduce the severe adverse effects of current treatments. The receptor for this nanoparticle is expressed in 20 types of cancer and associated with a poor prognosis, so this drug could open a new therapeutic pathway for other tumors.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Translational Research Institute) Scientists have developed a new cancer vaccine with the potential to activate the body's immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract223Ra-dichloride is a bone-seeking targeted alpha ( α)-emitting approved for bone metastases in prostate cancer. Here, we report a case of therapy-related acute promyelocytic leukemia (t-APL) following administration of223Ra, showing some evidence of a causative relationship. A patient with metastatic prostate cancer received therapy with223Ra, with 6 injections of the radiopharmaceutical at a standard dose of 55  kBq/kg at 4-week intervals for a cumulative administered activity of 26.3 MBq. PET/CT with18F-methylcholine repeated 1  month after the conclusion of223Ra was negative. After 8  ...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
In this study, six naturally occurring Notch inhibitors were isolated from the methanol (MeOH) extract ofLansium domesticum using our novel cell-based assay. Hongherin (2), a cardiac glycoside, demonstrated potent Notch inhibitory activity with an IC50 of 0.62  μM and was found to be cytotoxic in HPB-ALL human T cell acute lymphoblastic leukemia cells. Hongherin (2) also induced the differentiation of C17.2 neural stem cells to neurons, causing a 65% increase in differentiation compared to the control. Mechanistically, hongherin (2) reduced the amount of Notch1 (full length) and mastermind-like protein (MAML). This...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
Abstract Modifications at C6 and C7 positions of 3-cyanoquinolines 6 and 7 led to potent inhibitors of the ErbB family of kinases particularly against EGFRWT and Her4 enzymes in the radioisotope filter binding assay. The lead (4, SAB402) displayed potent dual biochemical activities with EGFRWT/Her4 IC50 ratio of 80 due to its potent inhibition of Her4 activity (IC50 0.03 nM), however, the selectivity towards activating mutations (EGFRL858R, EGFRex19del) was decreased. Inhibitor 4 also exhibited excellent growth inhibition in seven different cancer types and reduced cell viability in female NMRI nude mice in t...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
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