Investigating proteome changes between primary and metastatic cutaneous squamous cell carcinoma using SWATH mass spectrometry

Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in humans. It is responsible for 20 % of all non-melanoma skin cancer (NMSC) cases globally and attributing to as high as 20 % of skin cancer deaths [1,2]. While the majority of the cSCC lesions are curable with surgical removal [3], around 5% metastasize, and for biologically more aggressive tumours, this rate could be as high as 37 % [4]. The 5-year survival rate for cSCC patients with stage II disease (nodal disease) is 63 %, and for patients with stage III (metastatic) disease it is only 11 % [4].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research