Cardiac Allograft Vasculopathy and Secondary Outcomes of Hepatitis C Positive Donor Hearts at One-Year Post-Transplantation

The continued shortage of donor organs, together with a sustained increase in the number of potential donors with hepatitis C virus (HCV) infection (related to the ongoing opioid epidemic) and the advent of direct acting antiviral agents(DAA), has led to increased utilization of HCV-positive donors for heart transplantation(HT) (1). Furthermore, multiple recent studies have shown that 1-year HT-survival using HCV-positive donors in the current era of DAAs is similar to HT-survival using non-HCV donors (1,2).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research correspondence Source Type: research

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CONCLUSIONS: The distribution of sexually acquired HCV was sparsely scattered across countries/cities in the Asia-Pacific region. The threat of overlapping risk differed by locations, whereas transnational outbreaks remained uncommon. The paucity of information has hindered progress with comprehensive assessment in the Asia-Pacific region, where seroprevalence of HCV among HIV-positive MSM was relatively high. PMID: 32969173 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Since the THINKER (Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients) trial established that solid-organ transplantation from hepatitis C nucleic acid amplification test (NAT)+ kidney donors into hepatitis C –negative patients was possible without infecting recipients, an entirely new pool of organ donors became available.1 This era was ushered in by the advent of direct-acting antiviral agents that cure the vast majority of patients infected with hepatitis C. Over the last 5 decades, hepatitis C inf ection rates have dramatically fallen in the population but are now rising again due to the opioid epidemic.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
The purpose of this study was to acquire the epidemic trend of age-standardized reported incidence and to analyze the age effect, period effect, and cohort effect on the reported incidence of hepatitis C in Jilin Province, China. We collected the annual reported incidence data of hepatitis C by gender (2008–2017). Annual percentage change and annual average percentage change were calculated by joinpoint Poisson regression analysis. The age effect, period effect, and cohort effect on the incidence of hepatitis C were estimated by an age-period-cohort model, and the relative risk was determined. Joinpoint regression ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
In response to growing evidence of an expanding epidemic of sexually acquired hepatitis C virus (HCV) infection in HIV-positive MSM, the European AIDS Treatment Network (NEAT) acute hepatitis C consensus panel developed their first recommendations for HCV prevention and care during a consensus conference in May 2010 in Paris, France. As then, two major breakthroughs have changed the landscape. First, directly acting antivirals (DAA) with high levels of tolerability and HCV cure rates of over 95% are now widely available and will play a large role in the goal of elimination of HCV by 2030 (WHO sector strategy). Second, land...
Source: AIDS - Category: Infectious Diseases Tags: EDITORIAL REVIEW Source Type: research
Abstract In 2016, the World Health Organization (WHO) set hepatitis elimination targets of 90% reduction in incidence and 65% reduction in mortality worldwide by 2030 (1). Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection prevalences are high in Uzbekistan, which lacks funding for meeting WHO's targets. In the absence of large financial donor programs for eliminating HBV and HCV infections, insufficient funding is an important barrier to achieving those targets in Uzbekistan and other low- and middle-income countries. A pilot program using a catalytic funding model, including simplified test-and-treat ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
In 1989, a collaboration between the Centers for Disease Control (CDC) and a California biotechnology company identified the hepatitis C virus (HCV, formerly known as non-A, non-B hepatitis virus) as the causative agent in the epidemic of silent posttransfusion hepatitis resulting in cirrhosis. We now know that, the HCV genome is a 9.6 kb positive, single-stranded RNA. A single open reading frame encodes a 3011 amino acid residue polyprotein that undergoes proteolysis to yield 10 individual gene products, consisting of 3 structural proteins (core and envelope glycoproteins E1 and E2) and 7 nonstructural (NS) proteins (p7...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Society Paper Source Type: research
Hepatocellular carcinoma is among the leading causes of morbidity and mortality. Owing to the current epidemic of metabolic syndrome, the population affected by nonalcoholic fatty liver disease/nonalcoholic steatohepatitis continues to increase and now comprises a significant portion with those with hepatocellular carcinoma. The World Health Organization goal of obtaining universal hepatitis B virus vaccination has led to a global effort to improve vaccination, prevent mother-to-child transmission, and implement linkage to care to avoid the development of hepatocellular carcinoma. In contrast with the decreased burden of c...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
The current opioid use disorder (OUD) and nonopioid substance use epidemics in the United States have resulted in an increase in infections among persons who use drugs (PWUD), magnifying the morbidity and mortality associated with illicit substance use. Such infections that are increasing related to illicit opioid and other drug use include hepatitis C virus (HCV), hepatitis B virus, human immunodeficiency virus (HIV), invasive bacterial and fungal infections (including Staphylococcus aureus bacteremia, fungemia, endocarditis, skin and soft tissue infections), and bone and joint infections, among others.
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Tags: Preface Source Type: research
CONCLUSIONS: Although robust PDMPs and marijuana laws are promising, they do not target all outcomes, and multipronged interventions are needed. Future research should address marijuana laws, harm-reduction interventions, health insurer policies, patient/health care provider education, and the effects of simultaneous interventions on opioid-related outcomes. PMID: 32735190 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
The continued shortage of donor organs, together with a sustained increase in the number of potential donors with hepatitis C virus (HCV) infection (related to the ongoing opioid epidemic) and the advent of direct-acting anti-viral agents (DAAs), has led to increased utilization of HCV-positive donors for heart transplantation (HT).1 Furthermore, multiple recent studies have shown that 1-year HT survival using HCV-positive donors in the current era of DAAs is similar to the HT survival using non-HCV donors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: RESEARCH CORRESPONDENCE Source Type: research
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