Hypericin Accumulation as a Determinant of PDT Efficacy

AbstractEfficacy of photodynamic therapy (PDT) with hypericin was compared using two cell lines in monolayer culture. Photokilling was substantially impaired in the A549 (human ‐derived lung tumor) when compared with the 1c1c7 murine hepatoma. The efficacy of PDT with regard to photokilling was correlated with the steady‐state intracellular hypericin concentration. There was otherwise no difference in subcellular targets or the pathway to cell death: paraptosis. In a p rior study involving cell lines derived from patients with head and neck cancer, differences in response to PDT had shown no correlation with photosensitizer uptake.

Source: Photochemistry and Photobiology - June 28, 2020 Category: Science Authors: David Kessel Tags: RESEARCH NOTE Source Type: research