Bioactive Plasma Mitochondrial DNA is Associated with Disease Progression in Scleroderma Associated Interstitial Lung Disease

ConclusionThese findings demonstrate an unrecognized connection between EV ‐encapsulated mtDNA, clinical outcomes, and intracellular DNA‐sensing PRR activation in SSc‐ILD. Further study of these interactions could catalyze novel mechanistic and therapeutic insights into SSc‐ILD and related disorders.

Source: Arthritis and Rheumatology - June 29, 2020 Category: Rheumatology Authors: Changwan Ryu, Anjali Walia, Vivian Ortiz, Carrighan Perry, Sam Woo, Benjamin C. Reeves, Huanxing Sun, Julia Winkler, Jean E. Kanyo, Weiwei Wang, Milica Vukmirovic, Nicholas Ristic, Eric A. Stratton, Sita Ram Meena, Maksym Minasyan, Daniel K Tags: FULL LENGTH Source Type: research