Caring for Children With Multisystem Inflammatory Syndrome

Now, nearly two months after the first cases were reported, doctors can reassure parents that the syndrome remains rare, while continuing to urge vigilance.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Children and Childhood Pediatric Inflammatory Multisystem Syndrome (PIMS) Coronavirus (2019-nCoV) Kawasaki Disease Immune System Journal of the American Medical Assn Mount Sinai Medical Center Source Type: news

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By SAURABH JHA, MD The COVID-19 pandemic has been a testing time for the already testy academic discourse. Decisions have had to be made with partial information. Information has come in drizzles, showers and downpours. The velocity with which new information has arrived has outstripped our ability to make sense of it. On top of that, the science has been politicized in a polarized country with a polarizing president at its helm. As the country awoke to an unprecedented economic lockdown in the middle of March, John Ioannidis, professor of epidemiology at Stanford University and one of the most cited physician sc...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Health Policy Public Health John Ioannidis Saurabh Jha Source Type: blogs
Paolo Ferrero, Isabelle Piazza, Caterina Bonino, Matteo CiuffredaAnnals of Pediatric Cardiology 2020 13(3):230-233 There is limited information about coronavirus disease 2019 (COVID-19) in the pediatric population. Preliminary data suggest a not insignificant prevalence of cardiac involvement. Here, we report our early experience with COVID-19 in the pediatric population. These patients display exceptionally high levels of acute-phase reactants. The clinical syndrome in these patients is somewhat similar to Kawasaki disease with or without myocardial involvement. In some cases, the presentation mimics typical myocarditis....
Source: Annals of Pediatric Cardiology - Category: Cardiology Authors: Source Type: research
(AP) – At least 285 U.S. children have developed a serious inflammatory condition linked to the coronavirus and while most recovered, the potential for long-term or permanent damage is unknown, two new studies suggest. The papers, published online Monday in the New England Journal of Medicine, provide the fullest report yet on the condition. The condition is known as multisystem inflammatory syndrome in children. It is considered uncommon and deaths are rare; six children died among the 285 in the new studies. Including cases in Europe, where it was first reported, about 1,000 children worldwide have been affected, a...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Syndicated CBSN Boston Coronavirus Source Type: news
Authors: Rajapakse N, Dixit D Abstract Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute resp...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
A large European study confirms a rare bit of good news about COVID-19: children seem to be mostly spared from the worst of its effects. The paper, published June 25 in the Lancet Child &Adolescent Health, suggests well fewer than 1% of children who develop COVID-19 will go on to die from it, and the vast majority will not need intensive care. By contrast, in some of the world’s hardest-hit countries, case fatality ratios that include adults are estimated (albeit using preliminary data) to be higher than 10%. The new study analyzed case data from almost 600 pediatric COVID-19 patients from 21 different European ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
CONCLUSION: HScore can be used as a complement to clinical decision for initiating immunosuppression. Children with moderate-to-severe COVID-19, especially those with documented thrombocytopenia or chilblains, should be regularly monitored for coagulopathy. PMID: 32583809 [PubMed - as supplied by publisher]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
In late April 2020, alarming news emerged from Europe that a group of children with evidence of recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection had developed a severe illness, manifesting fever, hypotension requiring inotropic support, severe abdominal pain, and myocardial dysfunction with marked elevation in cardiac damage markers. This syndrome has been named pediatric multisystem inflammatory syndrome in Europe, and multisystem inflammatory syndrome in children (MIS-C) by the US Centers for Disease Control and Prevention.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Commentary Source Type: research
In 1967, he identified a disease that causes heart inflammation in children, one that Covid-19 has brought back into the news.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Kawasaki Disease Pediatric Inflammatory Multisystem Syndrome (PIMS) Deaths (Obituaries) Kawasaki, Tomisaku Coronavirus (2019-nCoV) Source Type: news
C, Anaya JM Abstract Coronavirus disease 2019 (COVID-19) has been categorized as evolving in overlapping phases. First, there is a viral phase that may well be asymptomatic or mild in the majority, perhaps 80% of patients. The pathophysiological mechanisms resulting in minimal disease in this initial phase are not well known. In the remaining 20% of cases, the disease may become severe and/or critical. In most patients of this latter group, there is a phase characterized by the hyperresponsiveness of the immune system. A third phase corresponds to a state of hypercoagulability. Finally, in the fourth stage organ i...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
There has been a rise in the number of critically ill patients presenting with an unusual clinical picture; all have in common features of Kawasaki disease and a confirmed or suspected coronavirus disease 2019 (COVID-19) infection. According to Harahsheh et  al, the diagnosis/treatment of Kawasaki disease was missed or delayed owing to the forced lockdown and doctors being focused on treating patients with COVID-19.1 A similar concern was shared by adult cardiologists, who observed a significant drop of admissions to coronary intensive care units beca use patients with acute myocardial infarction were afraid to risk i...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
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