Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a malignancy of B cells with a variable clinical course. Prognostication is important to place patients into different risk categories for guiding decisions on clinical management, to treat or not to treat. Although a number of clinical, cytogenetic and molecular parameters have been established, in the past decade, a tremendous understanding of molecular lesions has been obtained with the advent of high-throughput sequencing. Meanwhile, rapid advances in the understanding of the CLL oncogenic pathways have led to the development of small molecules targeting signal transducers, BTK and PI3K, as well as anti-apoptotic protein BCL2.

Source: Journal of Molecular Diagnostics - June 28, 2020 Category: Pathology Authors: Jimmy Lee, Y. Lynn Wang Tags: Review Source Type: research