Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
Source: Seminars in Immunopathology - Category: Pathology Source Type: research