Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study.

Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study. Environ Int. 2020 Jun 24;142:105870 Authors: Christiansen S, Axelstad M, Scholze M, Johansson HKL, Hass U, Mandrup K, Frandsen HL, Frederiksen H, Isling LK, Boberg J Abstract Exposure to mixtures of endocrine disrupting chemicals may contribute to the rising incidence of hormone-related diseases in humans. Real-life mixtures are complex, comprised of chemicals with mixed modes of action, and essential knowledge is often lacking on how to group such chemicals into cumulative assessment groups, which is an essential prerequisite to conduct a chemical mixture risk assessment. We investigated if mixtures of chemicals with diverse endocrine modes of action can cause mixture effects on hormone sensitive endpoints in developing and adult rat offspring after perinatal exposure. Wistar rats were exposed during pregnancy and lactation simultaneously to either bisphenol A and butylparaben (Emix), diethylhexyl phthalate and procymidone (Amix), or a mixture of all four substances (Totalmix). In male offspring, the anogenital distance was significantly reduced and nipple retention increased in animals exposed to Amix and Totalmix, and the mixture effects were well approximated by the dose addition model. The combination of Amix and Emix responded with more marked changes on these and other endocrine-sensitive endpoints than each binary mixture on it...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research