Influence of Metabolic Syndrome in Predicting Mortality Risk Influence of Metabolic Syndrome in Predicting Mortality Risk
It's well recognized that metabolic syndrome is a risk factor for mortality among obese adults, but does it pose the same risk in adults of normal weight?Preventing Chronic Disease
Publication date: Available online 8 July 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Prateek Srivastav, Suzanne Broadbent, Vaishali K, Baby Nayak, Vinod Bhat
Abstract Abnormal birth weight is the one of the major causes of adulthood diseases such as obesity, metabolic syndrome, cardiovascular disease, type 2 diabetes, and hypertension. Accumulating evidence has suggested that the placental trophoblast is one of the most important reasons that influence birth weight. Our previous study showed that miR-519a are correlated with low fetal birth weight through regulating trophoblast proliferation. To further clarify the detailed mechanisms on how it is regulated, we screened the placental-specific circular RNAs (circRNAs) via microarray assay. The result identified that cir...
Type 2 diabetes (T2D) is a metabolic disease characterized by increased inflammation, NOD-like receptors (NLRs) activation and gut dysbiosis. Our research group has recently reported that intestinal Th17 response limits gut dysbiosis and LPS translocation to visceral adipose tissue (VAT), protecting against metabolic syndrome. However, whether NOD2 receptor contributes intestinal Th17 immunity, modulates dysbiosis-driven metabolic tissue inflammation, and obesity-induced T2D remain poorly understood. In this context, we observed that mice lacking NOD2 fed a high-fat diet (HFD) display severe obesity, exhibit greater adipos...
ConclusionThese observations suggest that XN, DXN, and TXN may alleviate obesity ‐induced metabolic and neurocognitive impairments by targeting the liver‐brain axis.