Association between obesity and clinical prognosis in patients infected with SARS-CoV-2

In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2.MethodsThis is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People ’s Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2)  ≤ 300 mmHg. We grouped patients through the body mass index (BMI). Associations were examined using thet test,χ2 test and multivariate logistic forward regression test.ResultsPatients with BMI  
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research

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A lethal form of pneumonia leading to severe acute respiratory syndrome (SARS-CoV-2) caused by a new coronavirus is a disease detected in December 2019 in the People's Republic of China, in Wuhan (Hubei province). This condition quickly spread to other Chinese provinces and all over the world with currently more than 24 million infected patients with nearly 900,000 deaths affecting 188 countries (1-4). Data presented at the CROI 2020 (Conference on Retroviruses and Opportunistic Infection) held in Boston, Massachusetts last March, showed that the clinical spectrum of pneumonia was mild to moderate cases, 80% ; and 20% seve...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Objectives: To investigate patients’ characteristics, management, and outcomes in the critically ill population admitted to the ICU for severe acute respiratory syndrome coronavirus disease 2019 pneumonia causing an acute respiratory distress syndrome. Design: Retrospective case-control study. Setting: A 34-bed ICU of a tertiary hospital. Patients: The first 44 coronavirus disease 2019 acute respiratory distress syndrome patients were compared with a historical control group of 39 consecutive acute respiratory distress syndrome patients admitted to the ICU just before the coronavirus disease 2019 crisis. ...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
CONCLUSION: Obesity is associated with increased risk for intubation or death from COVID-19 in adults younger than 65 years, but not in adults aged 65 years or older. PRIMARY FUNDING SOURCE: National Institutes of Health. PMID: 32726151 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
In December 2019, many cases of pneumonia without a defined causative factor were reported in Wuhan China, with some patients rapidly developing respiratory distress syndrome or acute respiratory failure[1]. On Jan 7th, a novel coronavirus was identified by the Chinese Center for Disease Control and Prevention (CCDC) from the throat swab sample of a patient and was subsequently named 2019-nCoV by WHO[2]. The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
CONCLUSION: This initial description of a cohort of COVID-19 patients with and without ARDS in Germany reveals that those with ARDS more commonly have preexisting respiratory diseases and obesity, as well as persistently elevated inflammatory markers. COVID-19 patients without ARDS may likewise require prolonged hospitalization because of persistently elevated inflammatory values with a simultaneous need for supplemental oxygen. PMID: 32519944 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
This study provides the largest overview of autopsies of SARS-CoV-2-infected patients presented so far.
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
Researchers in Canada and China are testing a powerful immune booster that provides broad-spectrum protection against the common cold and a number of viruses including SARS, Ebola and H1N1. They’re currently running clinical trials to prove its effectiveness against coronavirus. I’m talking about quercetin – a powerful antioxidant that is already available as a supplement. Previous research shows that quercetin’s antiviral capacity works in three ways. Quercetin can: Stop the virus from infecting cells Reduce the reproduction of cells that are already infected And reduce infected cells resistance t...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
Coronavirus disease-2019 (COVID-19) is the infectious disease caused by the recently discovered coronavirus SARS-CoV-2. The first case of COVID-19 was reported to the World Health Organization (WHO) by Chinese authorities on December 31th 2019 as a result of a patient suffering pneumonia in Wuhan City, Hubei Province, China. Following a rapid spread in China, new outbreaks occurred in northern Italy and in several European countries. On March 12th 2020 WHO announced COVID-19 outbreak a pandemic.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Coronavirus disease-2019 (COVID-19) is the infectious disease caused by the recently discovered coronavirus SARS-CoV-2. The first case of COVID-19 was reported to the World Health Organization (WHO) by Chinese authorities on December 31st 2019 as a result of a patient suffering pneumonia in Wuhan City, Hubei Province, China. Following a rapid spread in China, new outbreaks occurred in northern Italy and in several European countries. On March 12th 2020 WHO announced COVID-19 outbreak a pandemic.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Tags: COVID-19 in Metabolism Source Type: research
One of the worst symptoms of any plague is uncertainty—who it will strike, when it will end, why it began. Merely understanding a pandemic does not stop it, but an informed public can help curb its impact and slow its spread. It can also provide a certain ease of mind in a decidedly uneasy time. Here are some of the most frequently asked questions about the COVID-19 pandemic from TIME’s readers, along with the best and most current answers science can provide. A note about our sourcing: While there are many, many studies underway investigating COVID-19 and SARS-CoV-19, the novel coronavirus that causes the illn...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Explainer Source Type: news
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