Natural Xanthone α‐Mangostin Inhibits LPS‐Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF‐κB Signaling Pathway

Conclusionα‐M inhibits microglia‐mediated neuroinflammation and prevents neurotoxicity and memory impairment from inflammatory damage. These results indicate that α‐M has great potential to be used as a nutritional preventive strategy for neuroinflammation‐related neurodegenerative disorders such as Alzheimer's disease.

Source: Molecular Nutrition and Food Research - June 27, 2020 Category: Food Science Authors: Huifeng Guan, Jiabing Li, Xiaofang Tan, Shenying Luo, Yangdan Liu, Yiwen Meng, Baichuan Wu, Yan Zhou, Yang Yang, Hongzhuan Chen, Lina Hou, Yu Qiu, Juan Li Tags: Research Article Source Type: research