ADP-heptose: a bacterial PAMP detected by the host sensor ALPK1.

ADP-heptose: a bacterial PAMP detected by the host sensor ALPK1.
Cell Mol Life Sci. 2020 Jun 26;:
Authors: García-Weber D, Arrieumerlou C
Abstract
The innate immune response constitutes the first line of defense against pathogens. It involves the recognition of pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs), the production of inflammatory cytokines and the recruitment of immune cells to infection sites. Recently, ADP-heptose, a soluble intermediate of the lipopolysaccharide biosynthetic pathway in Gram-negative bacteria, has been identified by several research groups as a PAMP. Here, we recapitulate the evidence that led to this identification and discuss the controversy over the immunogenic properties of heptose 1,7-bisphosphate (HBP), another bacterial heptose previously defined as an activator of innate immunity. Then, we describe the mechanism of ADP-heptose sensing by alpha-protein kinase 1 (ALPK1) and its downstream signaling pathway that involves the proteins TIFA and TRAF6 and induces the activation of NF-κB and the secretion of inflammatory cytokines. Finally, we discuss possible delivery mechanisms of ADP-heptose in cells during infection, and propose new lines of thinking to further explore the roles of the ADP-heptose/ALPK1/TIFA axis in infections and its potential implication in the control of intestinal homeostasis.
PMID: 32591860 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - June 25, 2020 Category: Cytology Authors: García-Weber D, Arrieumerlou C Tags: Cell Mol Life Sci Source Type: research