Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation.

Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation.
Trends Mol Med. 2020 Jul;26(7):670-682
Authors: Laman JD, 't Hart BA, Power C, Dziarski R
Abstract
Peptidoglycan (PGN) is a cell wall component of both Gram-positive and Gram-negative bacteria. Signature fragments of PGN are proinflammatory through engagement of pattern recognition receptors (PRR) on resident tissue cells and circulating leukocytes. Despite its abundance in the gut microbiota, there is limited recognition that PGN could contribute to chronic neuroinflammation. This review highlights current insights into the roles of PGN as a determinant of brain inflammation, notably in multiple sclerosis (MS) and its experimental autoimmune encephalomyelitis (EAE) models. Recent studies demonstrate PGN in blood of healthy adult humans. PGN amplifies autoimmune pathology via activation of innate immune cells. Novel uptake routes through (altered) gut mucosa by myeloid leukocyte subsets promote PGN transport to the brain.
PMID: 32589935 [PubMed - as supplied by publisher]

Source: Trends in Molecular Medicine - June 28, 2020 Category: Molecular Biology Authors: Laman JD, 't Hart BA, Power C, Dziarski R Tags: Trends Mol Med Source Type: research