Emerging Therapeutic Effects of Herbal Plants in Rheumatoid Arthritis.

Emerging Therapeutic Effects of Herbal Plants in Rheumatoid Arthritis. Endocr Metab Immune Disord Drug Targets. 2020 Jun 20;: Authors: Makkar R, Behl T, Kumar A, Nijhawan P, Arora S Abstract OBJECTIVES: Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by failure of spontaneous resolution of inflammation with lifetime perseverance, becoming one of the major causes of disability in millions of people. It is mainly characterized with progressive erosion of cartilage in response to formation of pannus leading to chronic polyarthritis and joint distortion. Early diagnosis and advances in molecular biology undoubtedly revolutionized therapeutic interventions in the past decade for better disease management. Despite favorable prospects, many patients still fail to respond to the current therapies urging a burning need to develop newer and safer medications. KEY FINDINGS: Herbal plants have been utilized since ancient era and provided base for massive bioactive compounds with flaunting therapeutic potential, many being advanced to drugs which are consumed worldwide for treating countless ailments. Scientific studies showed involvement of several cellular mechanisms like oxidative stress suppression, downregulated synthesis of proinflammatory cytokines namely interleukins (IL-1, IL-6), TNF-α, NF-κB, demoted metalloproteinases induced cartilage destruction and augmentation of free radical scavenging and...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research