Disrupted local innervation results in less VIP expression in CF mice tissues

Vasoactive Intestinal Peptide (VIP), which was discovered in the 1970s by Said and Mutt, is a 28-amino-acid neuropeptide that belongs to a superfamily of brain-gut peptide hormones which are structurally related [2]. This family includes significant neuropeptides such as the secretin, glucagon and pituitary adenylyl cyclase-activating peptide (PACAP) [3,4]. VIP immunoreactive nerve fibers originate from the central, peripheral and intrinsic nervous systems innervating all exocrine glands and blood vessels throughout the body.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research