Early Stage Node-Negative Postmastectomy Radiation Therapy —A Treatment Conundrum
A previously healthy 36-year-old premenopausal woman with no known family history of breast cancer presented with palpable nodules in her left breast. Diagnostic mammogram and ultrasound demonstrated an 8 × 4 cm area of segmental pleomorphic calcifications with scattered masses in the left breast at 7 to 8 o’clock. A biopsy of the anterior and posterior left breast lesions showed an invasive ductal carcinoma. Intermediate nuclear grade estrogen and progesterone receptors stained positive (>90%), and human epidermal growth factor receptor 2 (HER2) was equivocal by fluorescence in situ hybridization.
CONCLUSIONS: EPclin provided highly significant prognostic value and significant risk stratification for women with ILC. 10-year DR risk in the EPclin low risk groups were similar between ILC and IDC. Our results show that EPclin is informative in women with ILC and suggest that it is equally valid in both histological subtypes. PMID: 32561662 [PubMed - as supplied by publisher]
;a Mur C, Casamayor Franco MC Abstract INTRODUCTION: In early breast cancer (EBC), a single dose of intraoperative radiotherapy (IORT) might be an option to standard whole breast radiotherapy (WBRT). However, there is no consensus about its use and clinical results. AIM: to analyse the morbidity and oncological outcomes of IORT as monotherapy in EBC. METHODS: A single centre observational analytic study was performed. A prospective IORT cohort (2015-17) and a retrospective WBRT cohort (2012-17) were selected following the same criteria: ≥ 45 y.o., invasive ductal carcinoma or variants, radiologic...
In conclusion, preoperatively diagnosed non-mass-type DCIS represented an underestimation in approximately 27% of cases. In particular, the presence of a clinically abnormal palpation increases the chance of upstaging to invasive cancer. PMID: 32454975 [PubMed]
Publication date: Available online 22 May 2020Source: Current Medicine Research and PracticeAuthor(s): C. Lalchhandama, Lalawmpuii Pachuau, Lalchhanhimi, John Zohmingthanga, Nachimuthu Senthil Kumar
554Introduction: The aim of this study was to evaluate the relationship between the types of distant metastatic spread and the imaging features of primary tumor on PET/MRI for primary staging in newly diagnosed breast cancer-invasive ductal carcinoma (IDC) patients. Methods: The imaging data of 260 female patients with histopathologically diagnosed IDC who underwent whole body and breast dedicated 18F-FDG PET/MRI for primary staging between 2016-2019 in our department were evaluated retrospectively. Maximum and mean standardized uptake values (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), Tumor/Heal...
CONCLUSIONS: Community-detected breast cancers were associated with increased government and out-of-pocket costs. Implications for public health: These costs should be considered when evaluating current and alternative breast cancer screening strategies. PMID: 32311194 [PubMed - as supplied by publisher]
ConclusionsWe found a lower risk of radiation-induced secondary malignancies in LFS breast cancer patients than previously reported in the literature (33% risk of radiation-induced sarcoma). These findings suggest that LFS may not be an absolute contraindication for radiotherapy in breast cancer. The potential risk for locoregional recurrence without radiotherapy must be weighed against the long-term risk for radiation-induced malignancies in consideration of adjuvant radiotherapy for LFS breast cancer patients.
Abstract PURPOSE: To evaluate our long-term experience on one-day breast intraoperative radiotherapy (IORT) given as sole radiation treatment to selected patients with breast cancer. METHODS AND MATERIALS: Inclusion criteria of INTRAOBS study (prospective observational study) were: ER+ T1N0 unifocal ductal carcinoma; absence of lymphovascular invasion or of extensive intraductal component (Scarff-Bloom-Richardson grade III and HER2+++ excluded). Two different linacs were used (20Gy/1 fraction): one dedicated electron linac (
CONCLUSIONS: MBC has increasing incidence. PR-negative status was associated with better overall survival and disease-free interval. Indications to radiotherapy and hormonal therapy need standardization and will benefit from prospective randomized control trials. PMID: 32147980 [PubMed - in process]