Early Stage Node-Negative Postmastectomy Radiation Therapy —A Treatment Conundrum

A previously healthy 36-year-old premenopausal woman with no known family history of breast cancer presented with palpable nodules in her left breast. Diagnostic mammogram and ultrasound demonstrated an 8 × 4 cm area of segmental pleomorphic calcifications with scattered masses in the left breast at 7 to 8 o’clock. A biopsy of the anterior and posterior left breast lesions showed an invasive ductal carcinoma. Intermediate nuclear grade estrogen and progesterone receptors stained positive (>90%), and human epidermal growth factor receptor 2 (HER2) was equivocal by fluorescence in situ hybridization.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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CONCLUSIONS: EPclin provided highly significant prognostic value and significant risk stratification for women with ILC. 10-year DR risk in the EPclin low risk groups were similar between ILC and IDC. Our results show that EPclin is informative in women with ILC and suggest that it is equally valid in both histological subtypes. PMID: 32561662 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
;a Mur C, Casamayor Franco MC Abstract INTRODUCTION: In early breast cancer (EBC), a single dose of intraoperative radiotherapy (IORT) might be an option to standard whole breast radiotherapy (WBRT). However, there is no consensus about its use and clinical results. AIM: to analyse the morbidity and oncological outcomes of IORT as monotherapy in EBC. METHODS: A single centre observational analytic study was performed. A prospective IORT cohort (2015-17) and a retrospective WBRT cohort (2012-17) were selected following the same criteria: ≥ 45 y.o., invasive ductal carcinoma or variants, radiologic...
Source: Cirugia eEspanola - Category: Surgery Authors: Tags: Cir Esp Source Type: research
In conclusion, preoperatively diagnosed non-mass-type DCIS represented an underestimation in approximately 27% of cases. In particular, the presence of a clinically abnormal palpation increases the chance of upstaging to invasive cancer. PMID: 32454975 [PubMed]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
Publication date: Available online 22 May 2020Source: Current Medicine Research and PracticeAuthor(s): C. Lalchhandama, Lalawmpuii Pachuau, Lalchhanhimi, John Zohmingthanga, Nachimuthu Senthil Kumar
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
554Introduction: The aim of this study was to evaluate the relationship between the types of distant metastatic spread and the imaging features of primary tumor on PET/MRI for primary staging in newly diagnosed breast cancer-invasive ductal carcinoma (IDC) patients. Methods: The imaging data of 260 female patients with histopathologically diagnosed IDC who underwent whole body and breast dedicated 18F-FDG PET/MRI for primary staging between 2016-2019 in our department were evaluated retrospectively. Maximum and mean standardized uptake values (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), Tumor/Heal...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer I Source Type: research
CONCLUSIONS: Community-detected breast cancers were associated with increased government and out-of-pocket costs. Implications for public health: These costs should be considered when evaluating current and alternative breast cancer screening strategies. PMID: 32311194 [PubMed - as supplied by publisher]
Source: Australian and New Zealand Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Aust N Z J Public Health Source Type: research
ConclusionsWe found a lower risk of radiation-induced secondary malignancies in LFS breast cancer patients than previously reported in the literature (33% risk of radiation-induced sarcoma). These findings suggest that LFS may not be an absolute contraindication for radiotherapy in breast cancer. The potential risk for locoregional recurrence without radiotherapy must be weighed against the long-term risk for radiation-induced malignancies in consideration of adjuvant radiotherapy for LFS breast cancer patients.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Abstract PURPOSE: To evaluate our long-term experience on one-day breast intraoperative radiotherapy (IORT) given as sole radiation treatment to selected patients with breast cancer. METHODS AND MATERIALS: Inclusion criteria of INTRAOBS study (prospective observational study) were: ER+ T1N0 unifocal ductal carcinoma; absence of lymphovascular invasion or of extensive intraductal component (Scarff-Bloom-Richardson grade III and HER2+++ excluded). Two different linacs were used (20Gy/1 fraction): one dedicated electron linac (
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
CONCLUSIONS: MBC has increasing incidence. PR-negative status was associated with better overall survival and disease-free interval. Indications to radiotherapy and hormonal therapy need standardization and will benefit from prospective randomized control trials. PMID: 32147980 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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