High cholesterol: Consume this oil after your evening meal to lower cholesterol levels
HIGH cholesterol is a bad omen because it signals serious heart problems to come. Luckily, you can lower your cholesterol by making healthy dietary choices. To that end, a plant-based oil has proven to be a potent weapon against high cholesterol.
BEST supplements for cholesterol: Having too much cholesterol can block your blood vessels and make you more likely to have heart problems or stroke. So what can you do to lower cholesterol? Drinking a certain tea could help.
In this study, we summarized the current findings on how CH25H and 25HC play multiple roles to modulate cholesterol metabolism, inflammation, immunity, and antiviral infections. Overall, 25HC should be further studied as a potential therapeutic agent to control emerging infectious diseases in the future.
In this study, we developed a potent photoaffinity probe of the bisphosphonate esters through preliminary structure-activity relationship study and demonstrated binding of the bisphosphonate esters to the HMGCR membrane domain. These results provide an important clue to understand the elusive mechanism of the SR12813-mediated HMGCR degradation and serve as a basis to develop more potent HMGCR degraders that target the non-catalytic, membrane domain of the enzyme. PMID: 32616181 [PubMed - in process]
HIGH cholesterol levels are troublesome, because it means there's too much "bad" cholesterol floating in the blood - putting your life at risk. However, one popular breakfast food could reduce your chances of illness.
Contributors : Monta Ustinova ; Laura Ansone ; Ivars Silamikelis ; Vita Rovite ; Ilze Elbere ; Laila Silamikele ; Ineta Kalnina ; Davids Fridmanis ; Jelizaveta Sokolovska ; Ilze Konrade ; Valdis Pirags ; Janis KlovinsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly variable, emphasizing the need for reliable biomarkers. We chose the RNA-Seq-bas...
The objective of this study was to explore the molecular mechanisms of acute noise-induced hearing loss and recovery of steady-state noise-induced hearing loss using miniature pigs. We used miniature pigs exposed to white noise at 120 dB (A) as a model. Auditory brainstem response (ABR) measurements were made before noise exposure, 1 day and 7 days after noise exposure. Proteomic Isobaric Tags for Relative and Absolute Quantification (iTRAQ) was used to observe changes in proteins of the miniature pig inner ear following noise exposure. Western blot and immunofluorescence were performed for further quantitative and ...
Randomized clinical trials (RCT) have shown statin treatment to slow down the increase in carotid artery intima-media thickness (IMT) seen with ageing. However, those RCTs usually have a limited follow-up (1-3 years). Here an observational study was used to investigate the real-life effect of new statin treatment over a 10-year follow-up.
CONCLUSIONS: Both Martin and Sampson LDL-C estimates displayed significant proportion of upward discordance with reclassification to higher LDL-C categories compared to Friedewald formula, particularly in patients with elevated triglycerides and low LDL-C, a population in whom more accurate estimation of LDL-C is required. Further studies are warranted to validate the recently developed Sampson equation with comparison to Martin method that tended to more significantly overestimate LDL-C. PMID: 32612027 [PubMed - as supplied by publisher]
CONCLUSION: The promising anticancer potential of helenalin in various preclinical studies may open new avenues for therapeutic interventions in different tumors. Thus clinical trials validating its tumor suppressing and chemopreventive activities particularly in conjunction with standard therapies, are immediately required. PMID: 32614752 [PubMed - as supplied by publisher]
Authors: Brand C, Sehn AP, Gaya AR, Mota J, Brazosayavera J, Pollo Renner JD, Reuter CP Abstract PURPOSE: To verify the moderator role of physical fitness in the relationship betweenadiposity and cardiometabolic risk factors in normal weight and overweight/obese children and adolescents. METHODS: Cross-sectional study comprising 2482 children and adolescents, aged 7-17 years. Physical fitness was evaluated according the procedures of Projeto Esporte Brazil, and waist circumference (WC) with an inelastic tape. Cardiometabolic risk score was defined by the z-score sum of glucose, total cholesterol, high-density l...