His anemia was followed by searing foot pain. Seventeen years later, in precarious shape, a stellar athlete learned what was wrong.

A specialist’s blunt questions exposed the prolonged failure to diagnose and treat an elementary school principal for a disease that could have killed him.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

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Conclusion: Bone marrow/splenic aspiration still remains the gold standard test despite its risk and pain for patients. PMID: 32595711 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
In this report, it is presented a case with MM occurring in the right humerus after strain and presenting only shoulder pain without pathologic fracture.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings and outcomes of novel coronavirus disease-19 (COVID-19) in patients with transfusion dependent β thalassemia (β-thalassemia major-TM), non-transfusion dependent β thalassemia (β-thalassemia intermedia -TI) and sickle cell disease (SCD).Design, setting:A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies participated in the survey.Main outcome measures:Clinical, laboratory and radiologic findings and outcomes of patients with COVI...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Authors: Source Type: research
Multiple myeloma (MM) accounts for 10% of all haematological malignancies. Most MM patients present with anaemia, bone pain and elevated creatinine (1). Although very rare in MM patients, symptoms of hyperviscosity may occur including mucosal bleeding, loss of vision and neurologic abnormalities (2). Therapeutic apheresis is the standard of care in treating hyperviscosity syndrome (HVS) (3). Both bortezomib-based (4) and carfilzomib-based (5) strategies have been described to demonstrate a rapid decline in serum immunoglobulins (Ig).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
We present a case of a 47-year-old male with a history of diffuse large B-cell lymphoma (DLBCL) who was admitted for fatigue, persistent frontal headache and left upper-quadrant abdominal pain. Further investigation showed that he had pancytopenia with microangiopathic haemolytic anaemia (MAHA) and intracranial bleeding (ICB). Serum vitamin B12 and folate were later found to be low and a diagnosis of combined vitamin B12 and folate deficiency mimicking thrombotic thrombocytopenic purpura (TTP) was made. The patient responded well to vitamin B12 and folate replacement. PMID: 32568285 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
RARITAN, NJ, June 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the first randomized Phase 3 study investigating subcutaneous daratumumab[i] in the treatment of patients with newly diagnosed light chain (AL) amyloidosis, a rare and potentially fatal disease.[1],[2] The data demonstrated subcutaneous daratumumab in combination with cyclophosphamide, bortezomib, and dexamethasone (D-CyBorD) resulted in a higher hematologic complete response rate (CR), (53 percent vs. 18 percent [P
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
In conclusion, HbA reduces severity of HbS in HbS-β + thalassemia. HbS-HbD dis ease can manifest as a transfusion dependent illness. HbSS reduces severity of G6PD deficiency after first few years of life. HbSS and hemophilia coinheritance ameliorates symptoms of hemophilia.
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
A 19-year-old, non-smoker woman with a recent history of fever, nausea, vomiting, bloody diarrhea and loss of taste and smell was admitted to the Tor Vergata Hospital. A nasofaringeal swab resulted positive for SARS-CoV-2. At entry, she had a body temperature of 38  °C, pulse of 110 beats/min, and 99% oxygen saturation. She had severe anemia but no shortness of breath or chest pain. C-reactive protein, platelets, fibrinogen and d-dimer were elevated. A chest and abdominal CT scan showed no pneumonia but increased contrast enhancement in the ileum and colon.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
A 19-year-old, non-smoker woman with a recent history of fever, nausea, vomiting, bloody diarrhea and loss of taste and smell was admitted to the Tor Vergata Hospital. A nasofaringeal swab resulted positive for SARS-CoV-2. At entry, she had a body temperature of 38 °C, pulse of 110 beats/min, and 99% oxygen saturation. She had severe anemia but no shortness of breath or chest pain. C-reactive protein, platelets, fibrinogen and D-dimer were elevated. A chest and abdominal CT scan showed no pneumonia but increased contrast enhancement in the ileum and colon.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
tha Nanayakkara Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom I...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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