Inhibition of NADPH oxidase within midbrain periaqueductal gray decreases pain sensitivity in Parkinson's disease via GABAergic signaling pathway.

In conclusions, NOX4 activation of oxidative stress in the PAG of PD rats is likely to impair the descending inhibitory GABAergic pathways in regulating pain transmission and thereby plays a role in the development of pain hypersensitivity in PD. Inhibition of NOX4 has beneficial effects on the exaggerated pain evoked by PD.
PMID: 32584140 [PubMed - as supplied by publisher]

Source: Physiological Research - June 24, 2020 Category: Physiology Authors: Zhang W, Sun L, Yang X, Wang R, Wang H Tags: Physiol Res Source Type: research