Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial

In women with a singleton pregnancy and sonographic short cervix in mid-gestation, vaginal administration of progesterone reduces the risk of early preterm birth and improves neonatal outcomes, without any demonstrable deleterious effects on childhood neurodevelopment. In women with twin pregnancies the rate of spontaneous early preterm birth is 10-times higher than in singletons and in this respect all twins are at increased risk of preterm birth. However, six trials in unselected twin pregnancies reported that vaginal progesterone from mid-gestation had no significant effect on the incidence of early preterm birth.

Source: American Journal of Obstetrics and Gynecology - June 25, 2020 Category: OBGYN Authors: Anoop Rehal, Zs ófia Benkő, Catalina De Paco Matallana, Argyro Syngelaki, Deepa Janga, Simona Cicero, Ranjit Akolekar, Mandeep Singh, Petya Chaveeva, Jorge Burgos, Francisca S. Molina, Makrina Savvidou, Maria De La Calle, Nicola Persico, Maria Soledad Q Tags: Original Research: Obstetrics Source Type: research