Antibody tests for identification of current and past infection with SARSCoV2, Cochrane Database of Systematic Reviews

Background The severe acute respiratory syndrome coronavirus 2 (SARS ‐CoV‐2) virus and resulting COVID‐19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify current infection, rule out infection, identify people in need of care escalation, or to test for past infection and immune response. Serology tests to detect the presence of antibodies to SARS‐CoV‐2 aim to identify previous SARS‐CoV‐2 infection, and may help to confirm the presence of current infection. Objectives To assess the diagnostic accuracy of antibody tests to determine if a person presenting in the community or in primary or se condary care has SARS‐CoV‐2 infection, or has previously had SARS‐CoV‐2 infection, and the accuracy of antibody tests for use in seroprevalence surveys.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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This report describes the risks and concerns surrounding occupational transmission of SARS-CoV-2.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Coronavirus [CoV] MMWR Morbidity & Mortality Weekly Report Occupational Safety Health Transmission Workplace Safety COVID-19 Coronavirus Disease 2019 Source Type: news
CONCLUSIONS: This translational diagnostic tool will assist emergency and primary care clinicians, as well as out-of-hospital providers, in effectively managing people with suspected or confirmed SARS-CoV-2. PMID: 32633414 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
We examined the factors that increase the risk of mortality among hospitalized COVID-19 patients.Methods: This was a retrospective cohort study including confirmed COVID-19 patients admitted to the four Trinity Health of New England hospitals (THONE) in Connecticut and Massachusetts who either died or were discharged between March 1 –April 22, 2020. Demographics, comorbidities, and outcomes of care were extracted...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Authors: Tom J Abstract Relegated to clinical afterthought, the topic of infection control has never taken center stage in our modern dental sedation and anesthesiology practices. Surgical and procedural masks, gloves, gowns, protective eyewear, and appropriate surgical attire have remained de rigueur in both fashion and custom for decades. However, the emergence of certain seminal events throughout health care history has driven mandated changes when practitioners, staff, patients, and the surrounding communities were exposed or put at risk of exposure to infectious disease. Hepatitis, human immunodeficiency virus...
Source: Anesthesia Progress - Category: Anesthesiology Tags: Anesth Prog Source Type: research
Authors: Konturek PC, Harsch IA, Neurath MF, Zopf Y Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) outbreak is the most dramatic event since World War II. Originating as a cluster of unexplained cases of pneumonia, it turned out that this viral disease termed COVID-19 is not only a respiratory infection, but a systemic disease associated with a number of extrapulmonary complications. One of the medical disciplines that is strongly affected by this viral infection is gastroenterology. COVID-19 causes in some patients typical symptoms of enteritis such as diarrhea or abdominal pain. There is als...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Dworakowska D, Grossman AB Abstract COVID-19, which is caused by the single-stranded RNA severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has introduced significant therapeutic dilemmas in several areas. One of these is concern regarding the use of renin-angiotensin system (RAS) inhibitors. Dysfunction of the RAS has been observed in COVID-19 patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type-1 receptor blockers (ARBs), are associated with improved or worse clinical outcomes, remains unclear. RAS inhibitors are currently widel...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
The current pandemic caused by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has profoundly impacted nearly every aspect of society. While mitigation strategies have curbed the spread of the disease caused by SARS-CoV-2, COVID-19, these policies have had deleterious effects on the United States (US) economy, leading to a large contraction in the Gross Domestic Product (GDP). Spending on healthcare services comprises a sizable portion of the GDP, reductions in GDP, driven by the current pandemic milieu, could potentially harm patients who still need timely, high-quality care.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease.
Source: Virchows Archiv - Category: Pathology Source Type: research
Conclusion Proposed interventions for SARS-CoV-2 predominantly focus on viral microbiology and aim to inhibit viral cellular injury. While these therapies are promising, immediate use may not be feasible, and the time window of their efficacy remains a major unanswered question. An alternative approach is the modulation of the specific downstream pathophysiological effects caused by the virus that lead to morbidity and mortality. We propose a preponderance of evidence that supports clinical equipoise regarding the efficacy of RAAS-based interventions, and the imminent need for a multisite randomised controlled clinical tri...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: State of the Art Source Type: research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) pandemic has attracted interest because of its global rapid spread, clinical severity, high mortality rate and capacity to overwhelm healthcare systems [1, 2]. SARS-CoV-2 transmission occurs mainly through droplets, although surface contamination contributes and debate continues on aerosol transmission [3–5].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
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