Degenerative Disorders Account for Rising Share of U.S. Neurological Disease Deaths Degenerative Disorders Account for Rising Share of U.S. Neurological Disease Deaths

Neurological disease mortality rates in the U.S. are similar to what they were two decades ago, but over time the main cause of these deaths has shifted from cerebrovascular diseases to Alzheimer's dementia and other neurodegenerative disorders, a U.S. study finds.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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MRI scans show that accumulated iron in the outer layer of the brain is linked...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers DTI-MRI ties lack of fitness to cognitive decline Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Just one cup a day is enough to reduce the risk. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
Approximately 100,000 people died from Alzheimer's disease and dementia between February 2020 and May 2020, about 15,000 more than would have normally occurred.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This cohort study examines the association of early-life cognitive enrichment with late-life Alzheimer disease and other common dementia-related pathological changes in an autopsy sample.
Source: JAMA Neurology - Category: Neurology Source Type: research
Apathy is a motivational disturbance leading to reduced goal-oriented behavior. It afflicts a large percentage of patients suffering for Alzheimer's disease but it is also common in many neuropsychiatric disorders, including Parkinson's disease, frontotemporal dementia, stroke, and idiopathic depression. Apathy is disabling and adds to caregiver burden and distress. In an authoritative review, van Dyke et al1 summarize evidence indicating that compromise of the prefrontal cortex by the neuropathological changes of Alzheimer's disease lead to the lack of motivation characterizing apathy.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Editorial Source Type: research
Abstract We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Following four of the five lifestyle factors reduced Alzheimer's risk by 60 percent, the study found. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
This article presents the belief of some experts that patients always retain a basic, core underlying awareness. Practical approaches that careproviders and caregivers can take to maximize patients' quality of life are discussed. The possibility that patients and loved ones can find meaning in last months and years of life is emphasized. PMID: 32585653 [PubMed - in process]
Source: Journal of Clinical Ethics - Category: Medical Ethics Tags: J Clin Ethics Source Type: research
In this study, it was found that the prolidase activity was significantly higher (p = 0.0016) in AD subjects (5.62 ± 2.05 U/ mL) than control group (4.45 ± 0.92 U/ mL). The increase was significant beginning at mild AD (p = 0.006) with an inverse correlation with HMSE scores (p = 0.0344), thus implying that prolidase mediated alterations in ECM may be associated with the cognitive deficits seen in AD. PMID: 32590139 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Authors: Caselli RJ, Knopman DS, Bu G Abstract OBJECTIVE: To reassess the role of amyloid beta (Aβ) and the amyloid precursor protein (APP) system in the pathogenesis of Alzheimer's disease (AD). BACKGROUND: APP is a cell adhesion molecule that has been highly conserved over the course of phylogeny that has critical roles in brain development, synaptic plasticity, and the brain's intrinsic immune system. The amyloid cascade hypothesis describes a relatively linear, deterministic sequence of events triggered by a gain of Aβ peptide fragment toxicity that results in neurodegeneration and cognitive loss,...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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