Incidence of Invasive Fungal Infections in Acute Myeloid Leukemia without Antifungal Prophylaxis

The role of antifungal prophylaxis in acute myeloid leukemia (AML) continues to be controversial, with national guidelines recommending prophylaxis based on incidence of invasive fungal infection (IFI) to each region. We performed a retrospective, interrupted time series study based on periods where fluconazole was used or not used as prophylaxis during induction for AML. There was a decrease in IFI with fluconazole; however, this was largely driven by probable Aspergillus infection seen in our non-prophylaxis cohort. Our results suggest further investigation of azoles is warranted with consideration of including risk adapted strategies according to the rate of IFI.

Source: Clinical Lymphoma, Myeloma and Leukemia - June 25, 2020 Category: Hematology Authors: Jessie Signorelli, Matthew Lei, Jenna Lam, Marla Jalbut, Philip C. Amrein, Amir T. Fathi, Gabriela Hobbs, Hanno Hock, Steven Lawrence McAfee, Alyssa R. Letourneau, Rupa Narayan, Andrew Brunner Tags: Original Study Source Type: research