High HGF Expression Predicts Survival in Male Breast Cancer High HGF Expression Predicts Survival in Male Breast Cancer

What can hepatocyte growth factor tumor expression tell us about the prognosis of men with breast cancer?Breast Cancer Research
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

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Contributors : Edoardo Abeni ; Ilaria Grossi ; Eleonora Marchina ; Arianna Coniglio ; Fabio Facchetti ; Pietro Cavalli ; Fausto Zorzi ; Pier Luigi Chiodera ; Carlo Terenzio Paties ; Maria Luisa Crosatti ; Giuseppina De Petro ; Alessandro SalviSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensAbout 25% of familial breast cancer (BC) is attributed to germline mutations of BRCA1 and BRCA2 genes while the rest of patients are included in the BRCAX group. BC also affects men with a worldwide incidence of 1%. The epigenetic alterations, including those DNA methylation, have been rarely studied in t...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
This study evaluated the characteristics and care patterns for MBC compared with female breast cancer (FBC) in Japan.MethodsUsing the National Database of Hospital ‐Based Cancer Registries (HBCR) linked to the Diagnosis Procedure Combination data, we analyzed newly diagnosed breast cancer cases between January 2012 and December 2015 at participating hospitals in a large quality‐of‐care monitoring project. We employed logistic regression models to assess cancer treatment differences between MBC and FBC in patients who were indicated for adjuvant radiation therapy and neo‐adjuvant/adjuvant chemotherapy.ResultsOf 142,...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Background: Androgen receptor (AR) has been described to play a prominent role in male breast cancer (MBC). It maps on chromosome X, and recent reports indicate that X-chromosome polysomy is frequent in MBC. Since the response to anti-androgen therapy may depend on AR polysomy and on its overexpression similarly to prostate cancer, the aim of the present study was to investigate the DNA methylation level of AR and its coregulators, especially those mapped on the X-chromosome, that may influence the activity of AR in MBC.Methods: The DNA methylation level of AR, MAGEA2, MAGEA11, MAGEC1, MAGEC2, FLNA, HDAC6, and UXT, mapped ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeAndrogen Receptor (AR) positivity is often displayed in breast cancer and especially in Male Breast Cancer (MBC), where it appears to be a heterogeneous feature, with its expression ranging between 38 and 81% of cases. Given the fact that circulating androgens represent the most important sex hormones in males and that breast carcinogenesis is characteristically subjected to hormonal mechanisms, our purpose was to investigate the clinicopathological significance of AR in MBC assessing if its expression could be associated with parameters of tumor aggressiveness.MethodsClinical and pathological data were retr...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsAdherence to NCCNBRCA testing guidelines is high in this group of predominantly medical oncologists with extensive experience, with a high proportion having a genetic counselor in practice. Testing rates can be improved in patients with risk factors related to male relatives. High level of compliance to guidelines in a community setting is possible with a delivery model for genetic counseling and testing.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research
Authors: Duso BA, Trapani D, Marra A, D'Amico P, Guerini Rocco E, Fusco N, Mazzarella L, Criscitiello C, Esposito A, Curigliano G Abstract INTRODUCTION: Despite its rarity, male breast cancer shows a steadily rising incidence. Given the absence of ad hoc prospective randomized clinical trials, treatment strategies are based on extrapolation from female breast cancer recommendations or solely on population-based data. AREAS COVERED: This review discusses the current treatment landscape for male breast cancer in the adjuvant and in the metastatic setting. The authors also discuss the biology and genomic landscape...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Robyn Reddington, Morgan Galer, Amanda Hagedorn, Ehab Husain, Ravi Sharma, Valerie Speirs, Yazan Masannat
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionMale breast cancer is rare and patients usually present late, Lack of knowledge, public education, and embarrassment are the important related factors.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
British Journal of Cancer, Published online: 05 May 2020; doi:10.1038/s41416-020-0857-zSurvival benefit of tamoxifen in male breast cancer: prospective cohort analysis
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: The present results reveal that elevated MLRs (>0.30) and PLRs (>169.1) are associated with poor OS among male BC patients. Similarly, but insignificantly, an elevated NLR (>2.74) affected OS. PMID: 32344419 [PubMed - as supplied by publisher]
Source: Oncology - Category: Cancer & Oncology Authors: Tags: Oncology Source Type: research
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