Sensing cellular biochemistry with fluorescent chemical-genetic hybrids.

Sensing cellular biochemistry with fluorescent chemical-genetic hybrids.
Curr Opin Chem Biol. 2020 Jun 21;57:58-64
Authors: Gautier A, Tebo AG
Abstract
Fluorescent biosensors are powerful tools for the detection of biochemical events inside cells with high spatiotemporal resolution. Biosensors based on fluorescent proteins often suffer from issues with photostability and brightness. On the other hand, hybrid, chemical-genetic systems present unique opportunities to combine the strengths of synthetic, organic chemistry with biological macromolecules to generate exquisitely tailored semisynthetic sensors.
PMID: 32580134 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - June 20, 2020 Category: Biochemistry Authors: Gautier A, Tebo AG Tags: Curr Opin Chem Biol Source Type: research