mTORC and PKC ε in Regulation of Alcohol Use Disorder.

mTORC and PKCε in Regulation of Alcohol Use Disorder.
Mini Rev Med Chem. 2020 Jun 24;:
Authors: Hanim A, Mohamed IN, Mohamed RMP, Das S, Nor NSM, Harun RA, Kumar J
Abstract
Alcohol use disorder (AUD) is characterized by compulsive binge alcohol intake, leading to various health and social harms. Protein Kinase C epsilon (PKCε), a specific family of PKC isoenzyme, regulates binge alcohol intake and potentiates alcohol-related cues. Alcohol via upstream kinases like mammalian target to rapamycin complex 1 (mTORC1) or 2 (mTORC2), may affect the activities of PKCε or vice versa in AUD. mTORC2 phosphorylates PKCε at hydrophobic and turn motif, and mTORC2 was recently reported to be associated with alcohol seeking behavior, suggesting the potential role of mTORC2-PKCε interactions in pathophysiology of AUD. Mammalian target to rapamycin complex 1 (mTORC1), another form of mTOR complex regulates translation of synaptic proteins involved in alcohol-induced plasticity. Hence, in this article, we aimed to review the molecular composition of mTORC1 and mTORC2, drugs targeting PKCε, mTORC1, and mTORC2 in AUD, upstream regulation of mTORC1 and mTORC2 in AUD and downstream cellular mechanisms of mTORCs in pathogenesis of AUD.
PMID: 32579497 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - June 23, 2020 Category: Chemistry Authors: Hanim A, Mohamed IN, Mohamed RMP, Das S, Nor NSM, Harun RA, Kumar J Tags: Mini Rev Med Chem Source Type: research