In Early Trial, an Ancient Drug, Colchicine, Shows Promise Against Severe COVID-19

WEDNESDAY, June 24, 2020 -- There's new evidence that a 2,000-year-old medicine might offer hope against a modern scourge: COVID-19. The medication, called colchicine, is an anti-inflammatory taken as a pill. It's long been prescribed for gout, a...
Source: - Daily MedNews - Category: General Medicine Source Type: news

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Conclusions: Echocardiography may be useful for the management of selected COVID-19 patients, especially those with elevated D-Dimer and Troponin levels, in up to 16% of patients. PMID: 32963823 [PubMed]
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Authors: Hase R, Kurata R, Ishida K, Kurita T, Muranaka E, Mito H Abstract A 42-year-old man exhibiting hypoxia was diagnosed with coronavirus disease 2019. He had medical histories of type 2 diabetes, hyperlipidemia, hyperuricemia, and gout attack. He received favipiravir for compassionate use for 14 days. Subsequently, he showed increased uric acid levels and developed acute gouty arthritis. Favipiravir may induce not only hyperuricemia but also acute gouty arthritis. It should therefore be used with caution in patients with a history of gout and those with hyperuricemia, especially when used at a higher dose and...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
There comes a day in every woman ’s life when she must wonder: Where on earth have everyone’s manners gone? This phase of life, I once believed, was the same phase when I would shout things like: “You kids get off my lawn!” “Oh, it’s just a touch of gout!” And so on. Is it my […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician COVID-19 coronavirus Infectious Disease Source Type: blogs
We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. Since the patient refused admission to the hospital and had stable vital signs, we chose to treat him with a safe anti-inflammatory and non-immunosuppressive therapy. To hit two birds with one stone, we considered colchicine, as it has systemic anti-inflammatory effects and is also effective in gout flare. Unexpectedly, 48 hours after treatment, not only did his ongoing fever and toe pain disappe...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Colchicine, an anti-inflammatory drug used to treat gout and rheumatic disease, may be a promising treatment for COVID-19, a randomized, open-label trial suggests.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Cardiology News Source Type: news
A new study from the University of Athens in Greece found that 14% of coronavirus patients in a control group died compared to 1.8% in the group receiving colchicine, an old gout drug.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). Increase in blood uric acid level is a frequent side effect of favipiravir. Here, we discussed the mechanism of blood uric acid elevation during favipiravir treatment. Favipiravir is metabolized to an inactive metabolite M1 by aldehyde oxidase and xanthine oxidase, and excreted into urine. In the kidney, uric acid handling is regulated by the balance of reabsorption and tubular secreti...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
The search for existing drugs that may help treat coronavirus infections now has researchers testing the heartburn drug Pepcid, among others.
Source: L.A. Times - Health - Category: Consumer Health News Authors: Source Type: news
WEDNESDAY, April 22, 2020 -- As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place. The medication, called colchicine, is an oral...
Source: - Daily MedNews - Category: General Medicine Source Type: news
A new international clinical trial will examine if colchicine, a drug most often used to treat gout, can can reduce rates of hospitalization and death caused by the novel coronavirus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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