Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats

Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Wistar rats were submitted to microinjection of autologous blood (ICH) or saline (n  = 6 each side/group) into the R or L IC.

Source: Autonomic Neuroscience: Basic and Clinical - June 23, 2020 Category: Neuroscience Authors: Fernanda Ribeiro Marins, Marcelo Limbor ço-Filho, Bárbara Flecha D'Abreu, Pedro W. Machado de Almeida, Mariana Gavioli, Carlos Henrique Xavier, Stephen M. Oppenheimer, Sílvia Guatimosim, Marco Antônio Peliky Fontes Source Type: research