Critical Role of Intestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis.

In this study, we report that both Atf3-/- and CD4creAtf3fl/fl mice displayed profound dysbiosis of gut microbiota when compared with their littermate controls. The proinflammatory Prevotella taxa, especially Prevotella copri, were more abundant in ATF3-deficient mice when compared with littermate controls. This phenotype was obviously abrogated by adoptive transfer of either TFH cells or IgA+ B cells. Importantly, depletion of gut microbiota dramatically alleviated the severity of colitis in Atf3-/- mice, whereas transfer of microbiota from Atf3-/- mice to wild-type recipients increased their susceptibility to colitis. Collectively, these observations indicate the importance of IgA-microbiota interaction in ATF3-mediated gut homeostasis.
PMID: 32571839 [PubMed - as supplied by publisher]

Source: Journal of Immunology - June 21, 2020 Category: Allergy & Immunology Authors: Cao Y, Wang X, Yang Q, Deng H, Liu Y, Zhou P, Xu H, Chen D, Feng D, Zhang H, Wang H, Zhou J Tags: J Immunol Source Type: research