Staphylococcus aureus Population Structure and Genomic Profiles in Asymptomatic Carriers in Switzerland

Staphylococcus aureus is a leading cause for clinical infections and food intoxications, causing over 100,000 yearly cases of bacteremia in the United States and 434 food-borne outbreaks in the European Union. Approximately 30% of the population permanently carry S. aureus asymptomatically in their nasal cavity. The risk of infection and transmission to food items or the environment is higher in individuals that are nasally colonized. In addition, S. aureus can acquire various antimicrobial resistances leading to therapeutic failure, additional medical costs, and fatalities. Methicillin-resistant S. aureus (MRSA) cause a considerable burden of disease in humans and animals. MRSA carriage has been associated with animal and in particular livestock contact. Extensive current data on the virulence gene profiles, as well as data on antimicrobial resistance determinants is crucial in developing effective strategies to mitigate the burden of disease. To this end, we screened the anterior nares of 160 test subjects (87 pupils and 73 members of farmer families) in Switzerland for S. aureus carriage. A total of 73 S. aureus isolates were obtained. Factors such as exposure to farm or companion animals and personal medical history were recorded using a questionnaire. Using a DNA microarray, isolates were assigned to clonal complexes (CCs), and virulence and resistance gene profiles were determined. The collected strains were assigned to 20 CCs, among others CC1, CC7, CC8, CC15, CC30, CC...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Their numbers could rise to over 60 cases, authorities said on Friday. #safrica #omicronoutbreak
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Purpose of review The purpose of this review is to summarize the recent advances in Takayasu arteritis (TAK), mainly focusing on pathogenesis, imaging modalities, and management. Recent findings Three novel clusters based on angiographic findings were identified in the Indian cohort and replicated in the North American cohorts. Different new imaging modalities have been tried in the assessment of arterial inflammation with promising results. There is more evidence on the long-term use of tocilizumab, but relapses are common. In light of the recent findings on the pathogenesis of TAK, Janus kinase inhibitors seem...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: VASCULITIS SYNDROMES: Edited by Hasan Yazici and Yusuf Yazici Source Type: research
CONCLUSIONS: PST, which can be made through purchase of readily available poppy pods, carries risk for development of OUD and overdose. Herein we highlight the utility of a primary care opioid prescribing support team in empowering a primary care provider to prescribe BUP to treat a patient with complex OUD.PMID:34861895 | DOI:10.1186/s13722-021-00280-4
Source: Addiction Science and Clinical Practice - Category: Addiction Authors: Source Type: research
In conclusion, boron-containing composite carbon quantum dots appear to be the most suitable delivery system for treating COVID-19 infections especially when they are delivered through the lung.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
The five patients had mild symptoms and were among 12 known coronavirus cases linked to a wedding in Wisconsin late last month.
Source: L.A. Times - Health - Category: Consumer Health News Authors: Source Type: news
Conclusions Genomics will continue to drive advances in CVD prevention and management, and equitable progress is imperative. Nursing should leverage the public's trust and its widespread presence in clinical and community settings to prevent the worsening of CVD disparities among African Americans.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
Background Cardiovascular disease is a significant health problem in the United States, attributed to more than 30% of all deaths annually. Anxiety has been associated with cardiovascular disease risk and is thought to be associated with cardiovascular disease risk through inflammatory pathways. Objective The purposes of this study were to examine the relationship between anxiety and systemic inflammation in individuals at risk for cardiovascular disease and to determine if single-nucleotide polymorphisms (SNPs) associated with inflammation moderate this relationship. Methods A secondary analysis was cond...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
Conclusions Young adults are not armed with the accurate knowledge to make informed choices about using e-cigarettes. E-cigarette users are understudied and tend to value appearance and physical sensation over health. Social norms related to e-cigarette use are linked to perception of identity and the current technology-focused culture.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Literature Review Source Type: research
The Wisconsin Department of Health Services (DHS) and the City of Milwaukee Health Department are investigating a COVID-19 outbreak from a wedding in Milwaukee County on November 27. There are currently 12 confirmed cases among California residents who attended the event. One of the individuals attended the wedding upon return from international travel. A California State lab used genomic sequencing to identify that 5 of the 12 people diagnosed with COVID-19, were infected with the Omicron...(see release)
Source: Wisconsin DHFS Press Releases - Category: Hospital Management Authors: Source Type: news
Blasdell With increasing urbanisation, the dengue disease burden is on the rise in India, especially in large cities such as Mumbai. Current dengue surveillance in Mumbai includes municipal corporation carrying out specific activities to reduce mosquito breeding sites and the use of insecticides to suppress the adult mosquito populations. Clinical cases remain either underreported or misreported due to the restriction to government clinics, missing the large private health care sector. There is a need for an integrated approach to manage dengue outbreaks in Mumbai. There are various novel strategies available for use ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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