Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis

Conclusion: The evidence suggests an association between IEAT ( ≥ 5 days) and the risk of NEC. Further studies are needed to address whether the association with IEAT is causal.What is Known:•Necrotizing enterocolitis (NEC) is acute inflammatory necrosis of the intestinal tractin the newborn infant.•Some observational studies have associated initial empirical antibiotics with an increased risk of subsequent NEC.What is New:•Initial empirical antibiotic therapy (IEAT) ( ≥ 5 days) appear to increase the risk of NEC.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research