MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells.
MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells.
Virus Res. 2020 Jun 20;:198064
Authors: Ren T, Wang Y, Chen H, Wang K, Gao X, Liu L, Zhang Y, Sun Y
Abstract
MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/2009 influenza A virus replication by targeting viral HA and NS. However, whether microRNA ssc-miR-4331-5p (miR-4331-5p) regulates foot and mouth virus (FMDV) replication remains unclear. To explore the role of miR-4331-5p in FMDV infection, we detected the expression level of miR-4331-5p in porcine kidney (PK-15) cells. The results showed that FMDV infection directly upregulates miR-4331-5p expression, while transfection of mimics or inhibitor of miR-4331-5p promotes or inhibits FMDV replication. Further investigation clearly showed that miR-4331-5p increases FMDV replication through inhibiting type I interferon pathways. These data demonstrate that miR-4331-5p plays an important role in regulating FMDV replication.
PMID: 32574680 [PubMed - as supplied by publisher]
Source: Virus Research - Category: Virology Authors: Ren T, Wang Y, Chen H, Wang K, Gao X, Liu L, Zhang Y, Sun Y Tags: Virus Res Source Type: research
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