What is the difference between a Cochrane systematic review of interventions and a Cochrane diagnostic test accuracy review?
Cochrane systematic reviews of interventions (intervention reviews) and Cochrane diagnostic test accuracy reviews (DTA reviews) are two types of systematic review.They share the following characteristics:They aim to answer a specific healthcare question to help people make decisions based on up-to-date evidence from research. They look for all the relevant studies to answer the review question.They appraise the reliability of the studies.They summarize the results to produce a picture of the body of evidence available. They are systematic because they search for and analyze evidence in a systematic way, according to predetermined and published methods.Intervention reviewsIntervention reviews seek to answer questions about the effectiveness of healthcare interventions (medicines, treatments or policies) on the people who receive them. For example: ‘How effective is acupuncture for treating depression’; or ‘Which treatment is most effective for treating psoriasis?’. To answer such questions, the authors of intervention reviews identify studies that compare one intervention with either another intervention, an inactive intervention (pla cebo), or no intervention. Depending on the number and reliability of the studies identified, intervention reviews may provide information on whether the intervention works, or whether we need more evidence before we can draw a conclusion. They may identify for whom the intervention works best, whic h version o...
Authors: Ruini C, Nasifoglu S, Sattler E, Prinz J, Flaig MJ PMID: 32974717 [PubMed - in process]
Authors: Senner S, Fiocco Z, Eicher L, Flaig MJ PMID: 32974712 [PubMed - in process]
CONCLUSIONS: Our study pays attention on medium-long term effects of COVID-19 outbreak on inflammatory skin disorders, due to the lifestyle changes. In such context this review considers how a multidisciplinary approach, involving dermatologists, nutritionists and endocrinologists, may lead to a better management of dermatologic patients. PMID: 32969629 [PubMed - as supplied by publisher]
Molecules, Vol. 25, Pages 4424: 4-Hydroxy-7-Methoxycoumarin Inhibits Inflammation in LPS-activated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation Molecules doi: 10.3390/molecules25194424 Authors: Jin Kyu Kang Chang-Gu Hyun Coumarins are natural products with promising pharmacological activities owing to their anti-inflammatory, antioxidant, antiviral, anti-diabetic, and antimicrobial effects. Coumarins are present in many plants and microorganisms and have been widely used as complementary and alternative medicines. To date, the pharmacological efficacy of 4-hydroxy-7-methoxycoumarin (4H-7MTC...
ConclusionThe association of eosinophilic pneumonia with Ustekinumab, a drug used in the treatment of psoriasis and other autoimmune diseases, is rare and there is a paucity of literature regarding this association. PMID: 32962463 [PubMed - as supplied by publisher]
A 31-year-old male patient with psoriasis received administration of traditional Chinese medicine (TCM) during a disease course of 14 years. He showed multiple keratoma together with squamous cell carcinoma (SCC) in left lower limbs. After admission, the conditions were stable after treatment, and received surgery for treating SCC. The skin defect was treated using full-thickness skin graft. The postoperative survival of the flap was satisfactory, and the conditions of psoriasis were well controlled. In this case, we presented the feasibility of graft in the donor site from a psoriatic lesion. Besides, we analyzed the poss...
Conclusions: We expect to compile current evidence from published SRs/MAs of CHM for patients with psoriasis in an accessible and useful document. Ethics and dissemination: This study is a protocol for an overview of SRs/MAs that did not involve individual data. Thus, ethical approval is not required. OSF Registration number: DOI 10.17605/OSF.IO/VC654
Conclusion: IL-23 inhibitors are safe and efficacious therapeutic options for patients with psoriasis and should be considered as a potential first-line therapy alone or in combination with topical medications, phototherapy, and other systemic non-biologic agents. Consideration should be given to the evidence-based guidelines of global dermatologic organizations to help guide therapeutic decisions. PMID: 32962478 [PubMed - as supplied by publisher]